With the Passerini and Ugi reactions down, let's learn one more multi-component reaction, the Biginelli reaction. Developed by Pietro Biginelli in 1891, this reaction produces pyrimidine derivatives. What's the mechanism? What are the...

In the previous tutorial, we learned about some five-membered aromatic heterocycles. Those were furan, thiophene, and pyrrole. Now let's learn about a six-membered one, pyridine. This one is ubiquitous in nature, so let's get the scoop...

What are isonitriles good for? The Passerini reaction! This is a very neat multi-component reaction that is good for generating chemical libraries. When was it invented? What's the mechanism? What are we doing with it today? Let's find out!